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pentobarbital will reduce the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.Contraindicated (one)pentobarbital will reduce the extent or effect of cariprazine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is answerable for the development and e